Textul licitației

e aim to develop a microscopy-based infrastructure that enables both i) high-throughput phenotypic screening in 3D live advanced cell systems and ii) image-guided single-cell and intracellular component sampling. This infrastructure will serve scientists interested in screening relevant compound libraries in a wide variety of advanced fluorescent reporter cell systems (e.g., human stem cells cultured in 2D and differentiated in 3D microtissues such as liver or kidney organoids) and obtaining a mechanistic understanding of specific imaged phenotypes using a multi-omics approach. The microscope hardware must provide the following functionality: 1) Hardware: Label-free (brightfield or transmission), and lifetime microscopy. Time-lapse microscopy (incubator for a controlled environment). Confocal microscopy for 2D and 3D reporter cell systems cultured in multi-well plates. Automated high-con