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e fully compatible with the existing microscope and will replace the combination of the current camera and the outdated energy filter. In addition, it should provide the option to be re-mounted after an energy filter to allow for a future upgrade. The detector must enable high-speed data collection while preserving full temporal and spatial resolution. This purchase is carried out in the framework of the ERC Starting Grant “Actin in Action”. The research group Membrane Enzymology will use the upgraded microscope to study the molecular basis of actin-based motility of human pathogens. These samples are biochemically challenging, heterogeneous, and often available only in limited quantities. To obtain high-resolution cryogenic electron microscopy data, the detector must combine maximal acquisition speed, reproducibility, and image quality. The upgrade will ensure that the Talos Arctica